| University of Washington — Universal Flu Vaccine and Computational Protein Design (David Baker and Neil King) | University Of Washington | $11M | Nov 2017 | |
| California YIMBY — General Support (2025) | California YIMBY | $3M | May 2025 | |
| Duke University — CRISPR-Based Epigenome Editing Tools (Charles Gersbach) | Duke University | $3M | Oct 2018 | |
| United Kingdom Research and Innovation — Metascience Research | United Kingdom Research And Innovation | $2M | Oct 2024 | |
| University of California, Los Angeles — Social Science Genetic Association Consortium (2020) | Uc Los Angeles | $2M | Sep 2020 | |
| University of Notre Dame — Nanopore Protein Sequencing (Gregory Timp) | University Of Notre Dame | $2M | Jun 2017 | |
| University of Notre Dame — Nanopore Protein Sequencing (Gregory Timp) (2021) | University Of Notre Dame | $2M | Aug 2021 | |
| University of California, Los Angeles – Social Science Genetic Association Consortium (2023) | Uc Los Angeles | $2M | Jan 2024 | |
| UCSF — Communal Computing Technology | Uc San Francisco | $2M | Feb 2025 | |
| Purdue University — Preclinical Data Research (Douglas Brubaker) | Purdue University | $2M | Aug 2021 | |
| Convergent Research — General Support | Convergent Research | $1M | May 2025 | |
| The Argument — Operational Costs | The Argument | $1M | Jun 2025 | |
| New York University — Social Science Genetic Association Consortium (2023) | Nyu | $1M | Jan 2024 | |
| Innovation Growth Lab — General Support | Innovation Growth Lab | $1M | Jan 2025 | |
| Harvard University — Fluorescent Imaging for In Vivo Monitoring | Harvard University | $974K | Jan 2024 | |
| Animal Charity Evaluators — General Support (2024) | Animal Charity Evaluators | $900K | Mar 2024 | |
| Talent Mobility Fund — Help Desk for International Students | Fund For Global Talent Mobility | $778K | Jun 2025 | |
| Fair Share Housing Center — Legal Work in New Jersey (2025) | Fair Share Housing Center | $600K | Jun 2025 | |
| Dartmouth — Productivity Growth Project | Dartmouth College | $550K | Apr 2025 | |
| Center for Building in North America — Building Code Reform (2025) | Center For Building In North America | $500K | Feb 2025 | |
| YIMBY Melbourne — General Support | YIMBY Melbourne | $500K | Mar 2025 | |
| The Center for Scientific Integrity — Medical Evidence Project | The Center For Scientific Integrity | $450K | May 2025 | |
| Renaissance Philanthropy — Big if True Science Accelerator (2024) | Renaissance Philanthropy | $250K | Sep 2024 | |
| Renaissance Philanthropy — Big if True Science Accelerator (2025) | Renaissance Philanthropy | $250K | Apr 2025 | |
| Good Science Project — Analysis of U.S. R&D Funding | Good Science Project | $238K | Jun 2025 | |
| Abundance New York — Movement-building Efforts | Abundance New York | $150K | Jun 2025 | |
| Renaissance Philanthropy — Japanese Office | Renaissance Philanthropy | $150K | May 2025 | |
| Roots of Progress Institute — Annual Conference | Roots Of Progress Institute | $100K | Apr 2025 | |
| DesegregateCT — YIMBYtown (2025) | Desegregate CT | $75K | Feb 2025 | |
| University of Ottawa — Research Chairship | University Of Ottawa | $70K | Jan 2025 | |
| The Breakthrough Institute — Abundance Conference | The Breakthrough Institute | $50K | Mar 2025 | |
| Center for Open Science — Metascience 2025 Conference | Center For Open Science | $50K | Apr 2025 | |
| Asothia — Funding Opportunity Tool | Asothia | $14K | Jan 2025 | |