| Helen Keller International — Vitamin A Supplementation (January 2023) | Helen Keller International | $67M | Jan 2023 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (2023) | Malaria Consortium | $61M | Mar 2023 | |
| Evidence Action — Dispensers for Safe Water Program (February 2022) | Evidence Action | $49M | Feb 2022 | |
| Gates Philanthropy Partners — Tuberculosis Vaccine Candidate | Gates Philanthropy Partners | $40M | Feb 2023 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (February 2020) | Malaria Consortium | $34M | Feb 2020 | |
| Evidence Action — Scale-Up of In-Line Chlorination in India | Evidence Action | $33M | Jan 2024 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (2022) | Malaria Consortium | $32M | Mar 2022 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (December 2017) | Malaria Consortium | $28M | Dec 2017 | |
| Development Innovation Ventures — Scaling Up Global Health Interventions | Development Innovation Ventures | $28M | Jan 2023 | |
| Malaria Consortium — Support for LLIN Distribution Campaigns | Malaria Consortium | $27M | Apr 2021 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (December 2020) | Malaria Consortium | $27M | Dec 2020 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (December 2018) | Malaria Consortium | $27M | Dec 2018 | |
| Eleanor Crook Foundation — Global Malnutrition Regranting | Eleanor Crook Foundation | $25M | Mar 2023 | |
| IRD Global — Mobile Conditional Cash Transfers for Immunizations | IRD Global | $25M | Oct 2021 | |
| Gates Philanthropy Partners — Oral Cholera Vaccine Production | Gates Philanthropy Partners | $25M | Feb 2023 | |
| GiveDirectly — General Support (June 2015) | GiveDirectly | $25M | Jun 2015 | |
| Against Malaria Foundation — General Support (January 2016) | Against Malaria Foundation | $23M | Jan 2016 | |
| Against Malaria Foundation — Insecticide-Treated Bednets | Against Malaria Foundation | $22M | Jun 2024 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (2021) | Malaria Consortium | $22M | Mar 2021 | |
| Unlimit Health — Deworming and Worm Burden Mapping (2022) | Unlimit Health | $20M | Jan 2022 | |
| International Rescue Committee – Treatment of Malnutrition (May to August 2021) | International Rescue Committee | $20M | May 2021 | |
| New Incentives — General Support (2021) | New Incentives | $17M | Jan 2021 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention in Mozambique (2022) | Malaria Consortium | $16M | Feb 2022 | |
| Malaria Consortium — Support for SMC in FCT and Oyo States, Nigeria | Malaria Consortium | $16M | Oct 2021 | |
| Deworm the World Initiative — General Support (December 2017) | Evidence Action | $15M | Dec 2017 | |
| Against Malaria Foundation — General Support (January 2017) | Against Malaria Foundation | $15M | Jan 2017 | |
| Vital Strategies — RESET Alcohol Initiative | Vital Strategies | $15M | Jan 2022 | |
| Evidence Action — Accelerator Program | Evidence Action | $14M | Jan 2022 | |
| New Incentives – Conditional Cash Transfers in Nigeria | New Incentives | $14M | Jun 2022 | |
| Schistosomiasis Control Initiative — General Support (2017) | Schistosomiasis Control Initiative | $14M | Jan 2017 | |
| Evidence Action — Syphilis Screening and Treatment | Evidence Action | $13M | Aug 2022 | |
| Evidence Action — No Lean Season (December 2017) | Evidence Action | $12M | Dec 2017 | |
| Sightsavers — Deworming Programs (2023) | Sightsavers | $11M | Mar 2023 | |
| Deworm the World Initiative — General Support (January 2016) | Evidence Action | $11M | Jan 2016 | |
| Clinton Health Access Initiative – CHAI Incubator | Clinton Health Access Initiative | $10M | Sep 2022 | |
| Deworm the World Initiative — General Support (December 2018) | Evidence Action | $10M | Dec 2018 | |
| UC Davis — Malaria Gene Drive Feasibility Analysis (Greg Lanzaro) (2021) | University of California, Davis | $10M | Dec 2021 | |
| Tara Climate Foundation — Clean Energy Transition in Asia | Tara Climate Foundation | $10M | Dec 2022 | |
| GiveDirectly — General Support (January 2016) | GiveDirectly | $9.8M | Jan 2016 | |
| Helen Keller International — Vitamin A Supplementation (January 2020) | Helen Keller International | $9.7M | Jan 2020 | |
| Sightsavers — Deworming Programs (January 2019) | Sightsavers | $9.7M | Jan 2019 | |
| Malaria Consortium — Nigerian ITN Campaign | Malaria Consortium | $9.4M | Sep 2024 | |
| Evidence Action — Iron and Folic Acid Supplementation in India | Evidence Action | $9.2M | Sep 2022 | |
| Cincinnati Children’s Hospital Medical Center — Infant Immunome and Influenza Studies (Mary Staat) | Cincinnati Children’S Hospital Medical Center | $9.1M | Nov 2019 | |
| Nutrition International — Vitamin A Supplementation | Nutrition International | $9M | Feb 2022 | |
| Stanford University — Infant Immunome Study (Mark Davis, Justin Sonnenburg, and Bali Pulendran) | Stanford University | $8.3M | Mar 2020 | |
| Fortify Health — Support for Expansion | Fortify Health | $8.2M | Jan 2022 | |
| Helen Keller International — Vitamin A Supplementation (December 2020) | Helen Keller International | $8.1M | Dec 2020 | |
| Alliance for International Medical Action (ALIMA) — Malnutrition Treatment in Chad (May 2021) | Alliance For International Medical Action | $8M | Jun 2021 | |
| Evidence Action — Strengthen Operations (2019) | Evidence Action | $7.8M | Mar 2019 | |
| International Rescue Committee — Acute Malnutrition Treatment (January 2024) | International Rescue Committee | $7.5M | Mar 2024 | |
| Helen Keller International — Vitamin A Supplementation (January 2018) | Helen Keller International | $7.2M | Jan 2018 | |
| GiveDirectly — General Support (January 2014) | GiveDirectly | $7M | Jan 2014 | |
| Against Malaria Foundation — General Support (2020) | Against Malaria Foundation | $6.7M | Dec 2020 | |
| International Vaccine Institute — Cholera Vaccine Phase II Trial | International Vaccine Institute | $6.6M | Jun 2024 | |
| Helen Keller International — Vitamin A Supplementation (December 2018) | Helen Keller International | $6.5M | Dec 2018 | |
| Results for Development — Childhood Pneumonia Treatment Scale-Up | Results For Development | $6.4M | May 2016 | |
| New Incentives — General Support (November 2017) | New Incentives | $5.9M | Nov 2017 | |
| University of Edinburgh — Treatments for Preterm Birth | University of Edinburgh | $5.9M | Mar 2025 | |
| Results for Development — Childhood Pneumonia Treatment Program (2019) | Results For Development | $5.6M | Jan 2019 | |
| VasoRX — Atherosclerosis and Pulmonary Arterial Hypertension Therapy | VasoRX | $5.5M | Nov 2020 | |
| VasoRX — Atherosclerosis Investment | VasoRX | $5.4M | Apr 2018 | |
| IRD Global — Organizational Support | IRD Global | $5.4M | Jun 2023 | |
| GDI Solutions — Regranting | GDI Solutions | $5.3M | May 2025 | |
| Dalhousie University — Colostrum Research | Dalhousie University | $5.3M | Oct 2024 | |
| Telethon Kids Institute (University of Western Australia) — Strep A Vaccine (Jonathan Carapetis) | Telethon Kids Institute | $5.3M | Nov 2020 | |
| Evidence Action Beta — Incubator Program | Evidence Action Beta | $5.1M | Jul 2018 | |
| Givewell — General Support (2024) | GiveWell | $5.1M | Dec 2024 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention (February 2017) | Malaria Consortium | $5M | Feb 2017 | |
| The END Fund — Deworming (December 2016) | The END Fund | $5M | Dec 2016 | |
| Gates Philanthropy Partners — Global Education Regranting | Gates Philanthropy Partners | $5M | Feb 2023 | |
| EicOsis Human Health, Inc. — Pain Research | EicOsis Human Health, Inc. | $5M | Nov 2018 | |
| GiveDirectly — General Support (December 2014) | GiveDirectly | $5M | Dec 2014 | |
| Against Malaria Foundation — General Support (December 2014) | Against Malaria Foundation | $5M | Dec 2014 | |
| PATH — RTS,S Malaria Vaccine Implementation | PATH | $5M | Feb 2022 | |
| University of Connecticut Health Center — Syphilis Vaccine Development | University Of Connecticut Health Center | $4.6M | Jan 2022 | |
| VST Bio — Stroke Treatment | VST Bio | $4.5M | Jul 2020 | |
| Deworm the World Initiative — General Support (January 2017) | Evidence Action | $4.5M | Jan 2017 | |
| Evidence Action — In-Line Chlorination in Malawi | Evidence Action | $4.4M | Jul 2022 | |
| Sightsavers — Deworming Programs (October 2021) | Sightsavers | $4.4M | Oct 2021 | |
| Evidence Action — Deworm the World Initiative (March 2024) | Evidence Action | $4.4M | Mar 2024 | |
| MiracleFeet — Clubfoot Treatment Program | MiracleFeet | $4.3M | May 2023 | |
| GiveWell — General Support (2022) | GiveWell | $4.2M | Dec 2022 | |
| Evidence Action — Scale-Up of In-Line Chlorination in India (October 2023) | Evidence Action | $4.2M | Oct 2023 | |
| Evidence Action — Deworm the World Initiative | Evidence Action | $4.1M | Dec 2020 | |
| International Vaccine Institute — Hepatitis E Vaccine Trial | International Vaccine Institute | $4M | Jan 2022 | |
| Kyoto University — Reproductive Biology Research | Kyoto University | $4M | Oct 2023 | |
| Dezernat Zukunft — General Support and Re-Granting | Dezernat Zukunft | $4M | Jul 2021 | |
| Helen Keller International — Vitamin A Supplementation (April 2022) | Helen Keller International | $3.9M | Apr 2022 | |
| International Vaccine Institute — Strep A Vaccine Global Consortium | International Vaccine Institute | $3.6M | Jun 2023 | |
| GiveWell — General Support (2021) | GiveWell | $3.6M | Oct 2021 | |
| University of Amsterdam — HCV Vaccine Research | University Of Amsterdam | $3.5M | Oct 2023 | |
| Evidence Action Beta — Iron and Folic Acid Supplementation (“Phase 2”) | Evidence Action Beta | $3.4M | Nov 2018 | |
| Bridges to Prosperity — Trailbridge Building RCT in Rwanda | Bridges To Prosperity | $3.4M | May 2022 | |
| Global Priorities Institute — General Support (2021) | Global Priorities Institute | $3.3M | Jun 2021 | |
| Global Priorities Institute — General Support (2020) | Global Priorities Institute | $3.3M | Apr 2020 | |
| University of Washington — Protein Design Research (David Baker) | University of Washington | $3.3M | Nov 2021 | |
| University of Glasgow — Malaria Prevention Research (Steven Sinkins) | University of Glasgow | $3.2M | Oct 2020 | |
| Unlimit Health — General Support (2021) | Unlimit Health | $3.1M | Mar 2021 | |
| Global Priorities Institute — General Support | Global Priorities Institute | $3.1M | Feb 2018 | |
| Koch Institute for Integrative Cancer Research at MIT — Pneumonia Diagnostics | Koch Institute For Integrative Cancer Research | $3.1M | May 2023 | |
| International Centre of Insect Physiology and Ecology — Malaria Resistance Research | International Centre Of Insect Physiology And Ecology | $3M | Dec 2023 | |
| 1Day Sooner — General Support (2025) | 1Day Sooner | $3M | Feb 2025 | |
| California YIMBY — General Support (2023) | California YIMBY | $3M | Mar 2023 | |
| Our World in Data — General Support | Our World in Data | $3M | Jul 2025 | |
| Center for Global Development — General Support (2019) | Center for Global Development | $3M | Jun 2019 | |
| Center for Global Development — General Support 2016 | Center for Global Development | $3M | Feb 2016 | |
| Schistosomiasis Control Initiative — General Support (2014) | Schistosomiasis Control Initiative | $3M | Dec 2014 | |
| Sightsavers — Deworming (January 2017) | Sightsavers | $3M | Jan 2017 | |
| Beth Israel Deaconess Medical Center — Sepsis Therapy Clinical Trial (Michael Donnino) | Beth Israel Deaconess Medical Center | $2.9M | Jan 2018 | |
| Innovations for Poverty Action — Ethiopian Office | Innovations for Poverty Action | $2.8M | Feb 2023 | |
| Sightsavers — Deworming Programs (February 2021) | Sightsavers | $2.8M | Feb 2021 | |
| University of Georgia — Malaria Vaccine Research | University Of Georgia | $2.8M | Sep 2022 | |
| Centre for Effective Altruism — General Support (2019) | Centre for Effective Altruism | $2.8M | Feb 2019 | |
| Sightsavers — Deworming Programs (January 2020) | Sightsavers | $2.7M | Jan 2020 | |
| London School of Hygiene and Tropical Medicine — Research on Chronic Viral Infections | London School Of Hygiene And Tropical Medicine | $2.7M | Nov 2021 | |
| Evidence Action — Strengthen Operations | Evidence Action | $2.6M | Apr 2017 | |
| California YIMBY — General Support (2021) | California YIMBY | $2.6M | Jun 2021 | |
| University of Pennsylvania — Human Germ Cell Research (2023) | University of Pennsylvania | $2.6M | Dec 2023 | |
| GiveDirectly — General Support (December 2017) | GiveDirectly | $2.5M | Dec 2017 | |
| Against Malaria Foundation — General Support (December 2017) | Against Malaria Foundation | $2.5M | Dec 2017 | |
| The END Fund — Deworming Programs (December 2018) | The END Fund | $2.5M | Dec 2018 | |
| Schistosomiasis Control Initiative — General Support (2019) | Schistosomiasis Control Initiative | $2.5M | Mar 2019 | |
| Against Malaria Foundation — General Support (December 2018) | Against Malaria Foundation | $2.5M | Dec 2018 | |
| Sightsavers — Deworming Programs (January 2018) | Sightsavers | $2.5M | Jan 2018 | |
| Schistosomiasis Control Initiative — General Support (2018) | Schistosomiasis Control Initiative | $2.5M | Mar 2018 | |
| GiveDirectly — General Support (December 2018) | GiveDirectly | $2.5M | Dec 2018 | |
| The END Fund — Deworming Programs (December 2017) | The END Fund | $2.5M | Dec 2017 | |
| GiveDirectly — General Support (January 2017) | GiveDirectly | $2.5M | Jan 2017 | |
| Against Malaria Foundation — General Support (December 2019) | Against Malaria Foundation | $2.5M | Dec 2019 | |
| Stanford University — Hepatitis B Research | Stanford University | $2.5M | Feb 2024 | |
| International Vaccine Institute — Cholera Vaccine Clinical Trial | International Vaccine Institute | $2.5M | Jan 2022 | |
| The END Fund — General Support (December 2019) | The END Fund | $2.5M | Dec 2019 | |
| GiveDirectly — General Support (December 2019) | GiveDirectly | $2.5M | Dec 2019 | |
| Osaka University — Reproductive Biology Research | Osaka University | $2.5M | Jan 2024 | |
| African Union Development Agency — General Support (2020) | African Union Development Agency | $2.5M | Apr 2020 | |
| Dezernat Zukunft — Re-Granting (2022) | Dezernat Zukunft | $2.4M | Mar 2022 | |
| GiveWell — General Support (October 2020) | GiveWell | $2.4M | Oct 2020 | |
| Hemex Health — Diagnostic Products | Hemex Health | $2.3M | Dec 2023 | |
| IDinsight — Embedded GiveWell Team (2017) | IDinsight | $2.3M | May 2017 | |
| The University of Manitoba — Colostrum Research | University Of Manitoba | $2.3M | Oct 2024 | |
| GiveWell — General Support (January 2020) | GiveWell | $2.2M | Jan 2020 | |
| University of Bonn — Influenza Drug Development | University Of Bonn | $2.2M | Jul 2023 | |
| International Centre of Insect Physiology and Ecology — Malaria Prevention Research (Jeremy Herren) | International Centre Of Insect Physiology And Ecology | $2.2M | Nov 2020 | |
| Clinton Health Access Initiative — Health Technical Support Units | Clinton Health Access Initiative | $2.1M | Apr 2025 | |
| IDinsight — Endline Evaluation of New Incentives RCT | IDinsight | $2.1M | Aug 2019 | |
| Malaria Consortium — Monitoring and Evaluation of LLIN Distribution Campaign | Malaria Consortium | $2.1M | Jul 2021 | |
| California YIMBY — General Support (2019) | California YIMBY | $2M | Apr 2019 | |
| Dezernat Zukunft — Exit Grant | Dezernat Zukunft | $2M | May 2023 | |
| 1Day Sooner — General Support (2021) | 1Day Sooner | $2M | Nov 2021 | |
| Open New York — General Support (2023) | Open New York | $2M | Jul 2023 | |
| Kainomyx — Antimalarial Drug (2019) | Kainomyx | $2M | May 2020 | |
| IDinsight — General Support | IDinsight | $2M | Jun 2016 | |
| Georgia Institute of Technology — Portable Spectrometers (2024) | Georgia Institute of Technology | $2M | Aug 2024 | |
| University of Chicago — Research on Mobile Conditional Cash Transfers | University of Chicago | $2M | Jan 2022 | |
| The University of Queensland — StrepA Vaccine Research | The University Of Queensland In America | $2M | Nov 2023 | |
| UC Berkeley — In-Line Water Chlorination Devices (Amy Pickering) (2021) | University of California, Berkeley | $1.9M | Dec 2021 | |
| New Incentives — General Support (April 2020) | New Incentives | $1.9M | Apr 2020 | |
| New Incentives — General Support (2020) | New Incentives | $1.9M | Apr 2020 | |
| Center for Global Development — Migration Program | Center for Global Development | $1.8M | Mar 2017 | |
| The Center for Election Science — General Support (2019) | The Center for Election Science | $1.8M | Feb 2019 | |
| UC Berkeley — Follow-Up Research on Cash Transfers Study | University of California, Berkeley | $1.7M | Aug 2022 | |
| GiveWell — General Support (2023) | GiveWell | $1.7M | Dec 2023 | |
| Evidence Action — No Lean Season | Evidence Action | $1.7M | Dec 2016 | |
| Charity Entrepreneurship — General Support | Charity Entrepreneurship | $1.6M | Mar 2022 | |
| Oxfendazole Development Group — Oxfendazole Toxicity Tests | Oxfendazole Development Group | $1.6M | Jun 2022 | |
| Harvard University — CRISPR-Based Diagnostics for Febrile Diseases (2024) | Harvard University | $1.6M | Feb 2024 | |
| PATH — Malaria Vaccine Trial (2022) | PATH | $1.6M | Mar 2023 | |
| Impact Global Health — General Support | Impact Global Health | $1.6M | Mar 2022 | |
| Beth Israel Deaconess Medical Center — Long COVID Therapy Trial | Beth Israel Deaconess Medical Center | $1.5M | Mar 2023 | |
| Washington University in St. Louis — Omega-3 Trial for Pregnant Women | Washington University in St. Louis | $1.5M | Jan 2023 | |
| Deworm the World Initiative — General Support (December 2013) | Evidence Action | $1.5M | Dec 2013 | |
| UC Davis — Malaria Gene Drive Feasibility Analysis (Greg Lanzaro) | University of California, Davis | $1.5M | Feb 2020 | |
| University Health Network — Hepatitis C Challenge Model | University Health Network | $1.5M | Mar 2024 | |
| Center for Popular Democracy — Fed Up Campaign (2016) | Center For Popular Democracy | $1.4M | Dec 2015 | |
| University of Oxford — Hepatitis C Challenge Model | University of Oxford | $1.4M | Apr 2024 | |
| University of Pennsylvania — Adrenal Cell Research | University of Pennsylvania | $1.3M | Dec 2022 | |
| USAIM — Seasonal Migration from Haiti | U.S. Association For International Migration | $1.3M | Jul 2014 | |
| Against Malaria Foundation — General Support (December 2012) | Against Malaria Foundation | $1.3M | Dec 2012 | |
| Employ America — Exit Grant | Employ America | $1.3M | Jan 2022 | |
| Employ America — General Support (2021) | Employ America | $1.3M | May 2021 | |
| Khon Kaen University — Tuberculosis Diagnostic via Raman Spectroscopy | Khon Kaen University | $1.2M | Dec 2022 | |
| University Health Network — Preterm Birth Research (2020) | University Health Network | $1.2M | Oct 2020 | |
| Washington University in St. Louis — Research on Cryptosporidium Hominis (2023) | Washington University in St. Louis | $1.2M | Jun 2023 | |
| Center for Popular Democracy — Fed Up Campaign (2018) | Center For Popular Democracy | $1.2M | Feb 2018 | |
| IDinsight — Embedded GiveWell Team (2018) | IDinsight | $1.2M | Apr 2018 | |
| Center for Global Development — Labor Mobility Research | Center for Global Development | $1.2M | Mar 2014 | |
| Washington University in St. Louis — Research on Cryptosporidium Hominis (David Sibley) | Washington University in St. Louis | $1.2M | Nov 2020 | |
| Center for Global Development Europe — Education Research | Center for Global Development | $1.1M | Oct 2022 | |
| Princeton University — Marmoset Model for Hepatitis B | Princeton University | $1.1M | Mar 2025 | |
| Center for Effective Global Action at UC Berkeley — KLPS-4 Survey | University of California, Berkeley | $1.1M | Apr 2017 | |
| Center for Popular Democracy — Fed Up Campaign (2017) | Center For Popular Democracy | $1.1M | Feb 2017 | |
| Malaria Consortium — Monitoring and Evaluation of Net Distribution in Anambra, Nigeria | Malaria Consortium | $1.1M | Dec 2021 | |
| University of Rochester — Rural-Urban Migration in Kenya | University Of Rochester | $1.1M | Oct 2021 | |
| University of Southern California — Clinical Trial for Preterm Birth Supplements | University of Southern California | $1.1M | Oct 2024 | |
| University of Washington — Syphilis Vaccine Development (Lorenzo Giacani) (2024) | University of Washington | $1M | Jun 2024 | |
| Translational Health Science and Technology Institute — Henipavirus Antivirals | Translational Health Science And Technology Institute | $1M | Aug 2022 | |
| IRD Global — RCT Planning for Tuberculosis Program | IRD Global | $1M | Sep 2022 | |
| Charak Foundation — Ramatroban Clinical Trial | Charak Foundation | $1M | Mar 2022 | |
| Alliance for International Medical Action — Treatment of Malnutrition in Niger | Alliance For International Medical Action | $1M | Jan 2021 | |
| University of Ottawa — Institute for Replication (2024) | University of Ottawa | $1M | Dec 2024 | |
| Employ America Action Fund – General Support | Employ America Action Fund | $1M | Apr 2021 | |
| Founders Pledge — General Support (2021) | Founders Pledge | $1M | Nov 2021 | |
| International Refugee Assistance Project — Exit Grant | International Refugee Assistance Project | $1M | Jul 2022 | |
| 1Day Sooner — General Support (2023) | 1Day Sooner | $1M | Oct 2023 | |
| Open New York — General Support | Open New York | $1M | Aug 2021 | |
| Center for Global Development — Migration Program (2020) | Center for Global Development | $1M | Mar 2020 | |
| International Refugee Assistance Project — General Support (2020) | International Refugee Assistance Project | $1M | Nov 2020 | |
| Schistosomiasis Control Initiative — General Support (2016) | Schistosomiasis Control Initiative | $1M | Jan 2016 | |
| Mercy Corps — Seasonal Migration Pilot Project and RCT | Mercy Corps | $1M | Apr 2020 | |
| Containment of Artemisinin Resistance in Eastern Myanmar | Population Services International | $1M | Aug 2012 | |
| International Refugee Assistance Project — General Support (2019) | International Refugee Assistance Project | $1M | Jan 2019 | |
| Employ America — General Support (October 2019) | Employ America | $1M | Oct 2019 | |
| Employ America — General Support (2020) | Employ America | $1M | Jul 2020 | |
| VenomAid — Rapid Diagnostics for Snakebites | VenomAid | $990K | Jun 2022 | |
| Stanford University — Preclinical Research on Hepatitis B (Jeffrey Glenn) | Stanford University | $915K | May 2020 | |
| CDC Foundation — Malaria Control Research Project (2023) | CDC Foundation | $900K | Jul 2023 | |
| gui2de — Zusha! Road Safety Campaign (February 2017) | Georgetown University | $900K | Feb 2017 | |
| University of Notre Dame — Biofilm-Resistant Catheters | University of Notre Dame | $895K | Dec 2022 | |
| UCSF — Organ Regenerative Surgery (Tammy Chang) | University of California, San Francisco | $825K | Jun 2017 | |
| New Incentives — General Support (April 2017) | New Incentives | $820K | Apr 2017 | |
| University of Washington — Syphilis Vaccine Development (Lorenzo Giacani) | University of Washington | $816K | Aug 2021 | |
| Evidence Action — No Lean Season (March 2016) | Evidence Action | $812K | Mar 2016 | |
| Evidence Action — Impact Evaluation of Iron and Folic Acid Supplementation (“Phase 2”) | Evidence Action | $800K | Mar 2019 | |
| Evidence Action — General Operating Support | Evidence Action | $800K | Dec 2017 | |
| Center for Global Development — Oral COVID Antivirals | Center for Global Development | $800K | Feb 2022 | |
| Purdue University — Imatinib Trial for Drug-Resistant Malaria (2023) | Purdue University | $780K | Aug 2023 | |
| University Of Science Technical And Technologies De Bamako — Malaria Vaccine Clinical Trial (Alassane Dicko) | University Of Science Technical And Technologies De Bamako | $755K | Aug 2021 | |
| GiveWell — General Support (2018) | GiveWell | $751K | Jun 2018 | |
| Schistosomiasis Control Initiative — General Support (2013) | Schistosomiasis Control Initiative | $750K | Dec 2013 | |
| Center for Popular Democracy — Fed Up Campaign (2015) | Center For Popular Democracy | $750K | Jan 2015 | |
| Washington Center for Equitable Growth — Macroeconomic Policy Research | Washington Center For Equitable Growth | $750K | Nov 2019 | |
| International Vaccine Institute — Hepatitis E and Leptospirosis Study | International Vaccine Institute | $742K | Sep 2023 | |
| Flanders Institute of Biotechnology — Syphilis Vaccine Research | Flanders Institute Of Biotechnology | $732K | Jun 2022 | |
| Center for Global Development — Labor Mobility Partnerships | Center for Global Development | $710K | Mar 2019 | |
| PATH — Health Technical Support Unit | PATH | $704K | May 2025 | |
| ANTI-VeC — Malaria Prevention Research | ANTI VeC | $700K | Oct 2020 | |
| International Refugee Assistance Project — General Support (2016) | International Refugee Assistance Project | $700K | May 2016 | |
| Economic Policy Institute — Macroeconomic Policy Research (2018) | Economic Policy Institute | $700K | Jul 2018 | |
| Effective Altruism Foundation — European Policy Research and Advocacy (January 2022) | Effective Altruism Foundation | $697K | Jan 2022 | |
| Rethink Priorities — Global Health and Wellbeing Research (2022) | Rethink Priorities | $690K | Dec 2022 | |
| CDC Foundation — Malaria Control Research Project (2021) | CDC Foundation | $673K | Mar 2021 | |
| YIMBY Alliance — Pro-Housing Advocacy | YIMBY Alliance | $672K | Feb 2023 | |
| Rethink Priorities — General and Research Support (2023) | Rethink Priorities | $670K | Nov 2023 | |
| CDC Foundation — Reproductive Health Data Analysis (Dmitry Kissin) | CDC Foundation | $662K | Feb 2020 | |
| Sightline Institute — Housing Reform in Washington and Oregon (2023) | Sightline Institute | $660K | Jul 2023 | |
| Mercy Corps — Seasonal Migration RCT in Niger | Mercy Corps | $650K | Oct 2022 | |
| Institut des Sciences et Techniques, Bobo-Dioulasso — Malaria Vaccine Clinical Trial (Jean Bosco Ouedraogo) | Institut Des Sciences Et Techniques, Bobo Dioulasso | $631K | Aug 2021 | |
| Institut de Recherche en Sciences de la Santé — Malaria Vaccine Clinical Trial (Halidou Tinto) | Institut De Recherche En Sciences De La Santé | $630K | Aug 2022 | |
| The Center for Election Science — General Support (2017) | The Center for Election Science | $629K | Dec 2017 | |
| Harvard University — CRISPR-Based Diagnostics for Febrile Diseases | Harvard University | $600K | Dec 2021 | |
| Sightline Institute — Housing Reform in Washington and Oregon (2021) | Sightline Institute | $600K | Nov 2021 | |
| Abundant Housing Massachusetts — General Support (2023) | Abundant Housing Massachusetts | $600K | Mar 2023 | |
| Purdue University — Imatinib Trial for Drug-Resistant Malaria | Purdue University | $600K | Sep 2022 | |
| Data for India — Public Health and Development Data Analysis | Data For India | $600K | Aug 2024 | |
| Abundant Housing Massachusetts — General Support (2021) | Abundant Housing Massachusetts | $600K | Mar 2021 | |
| Sightline Institute — Housing and Urban Development (December 2019) | Sightline Institute | $600K | Dec 2019 | |
| Center for Popular Democracy — Fed Up Campaign (2019) | Center For Popular Democracy | $600K | Nov 2019 | |
| Center for Global Development — COVID-19 Net Health Impact Calculations | Center for Global Development | $550K | Apr 2020 | |
| Protect the People — Seasonal Migration from Haiti | Protect The People | $550K | Feb 2016 | |
| Economic Policy Institute — Macroeconomic Policy Research (2020) | Economic Policy Institute | $550K | Aug 2020 | |
| Precision Development – Trial Scoping | Precision Development | $540K | Apr 2022 | |
| GiveWell — General Support (2017) | GiveWell | $531K | Oct 2017 | |
| GiveWell — Top Charity “Participation” Grants (2016) | GiveWell | $500K | Sep 2016 | |
| GiveWell — Top Charity “Participation” Grants (2015) | GiveWell | $500K | Jan 2015 | |
| GiveWell — Top Charity “Participation” Grants (2014) | GiveWell | $500K | May 2014 | |
| Center for Building in North America — Housing Code Reform | Center For Building In North America | $500K | Sep 2022 | |
| The END Fund — General Support (2021) | The END Fund | $500K | Dec 2021 | |
| University of Maine — Biofilm-Resistant Catheters | University Of Maine | $500K | Aug 2022 | |
| GiveDirectly – General Support (2022) | GiveDirectly | $500K | Jan 2022 | |
| Malengo — General Support | Malengo | $500K | Feb 2024 | |
| UC San Diego — Antimalarial Gene Drive Research | University Of California, San Diego | $500K | Apr 2025 | |
| Unlimit Health – General Support (2022) | Unlimit Health | $500K | Jan 2022 | |
| UC Davis — Insectary for Malaria Gene Drive Research | University of California, Davis | $500K | Apr 2024 | |
| YIMBY Law — General Support (2022) | YIMBY Law | $500K | Jun 2022 | |
| Open New York — Housing Advocacy in New York (2022) | Open New York | $500K | Sep 2022 | |
| The END Fund — General Support (2020) | The END Fund | $500K | Dec 2020 | |
| GiveDirectly — General Support (2021) | GiveDirectly | $500K | Jan 2021 | |
| Affordable Maryland — Advocacy for Affordable Housing and Land Use Reform | Affordable Maryland | $500K | Jun 2022 | |
| Stanford University — Immunization Research (2023) | Stanford University | $500K | Sep 2023 | |
| Labor Mobility Partnerships — International Labor Mobility | Labor Mobility Partnerships | $500K | Aug 2020 | |
| GiveDirectly — General Support (December 2012) | GiveDirectly | $500K | Dec 2012 | |
| Service Delivery Indicators Project | International Development Association | $500K | Mar 2014 | |
| Alliance for Open Society International: Albanian Renaissance | Alliance For Open Society International | $500K | Jul 2014 | |
| Center for Popular Democracy — Exit Grant | Center For Popular Democracy | $500K | Mar 2022 | |
| YIMBY Law — General Support (October 2020) | YIMBY Law | $500K | Oct 2020 | |
| Center for American Progress — Macroeconomic Stabilization | Center For American Progress | $500K | Mar 2016 | |
| California YIMBY — General Support (April 2018) | California YIMBY | $500K | Apr 2018 | |
| Economic Policy Institute — Macroeconomic Policy Research (2016) | Economic Policy Institute | $500K | Jun 2016 | |
| Rita Allen Foundation — Fellowship Support | Rita Allen Foundation | $495K | Apr 2019 | |
| Center for Effective Global Action at UC Berkeley — Scoping RCTs for Follow-Up | University of California, Berkeley | $492K | Jul 2017 | |
| IDinsight — Beneficiary Preferences Survey | IDinsight | $474K | Mar 2019 | |
| KEMRI-Wellcome Trust Research Programme — Malaria Vaccine Clinical Trial (Philip Bejon) | The KEMRI Wellcome Trust Research Programme | $472K | Aug 2021 | |
| Center for Popular Democracy — Fed Up Campaign (2020) | Center For Popular Democracy | $465K | Jun 2020 | |
| Futurewise — Housing Advocacy in Washington | | $450K | Apr 2023 | |
| Greater Greater Washington — Housing and Land Use Reform (2021) | Greater Greater Washington | $450K | Dec 2021 | |
| New York University — Ethiopia Urban Expansion Initiative Follow-Up | New York University | $450K | Nov 2022 | |
| George Mason University — Michael Clemens Migration Research | George Mason University | $450K | Nov 2022 | |
| Yale University — Cardiovascular Disease Therapy Research | Yale University | $450K | Nov 2020 | |
| CalHDF — General Support (2023) | CalHDF | $440K | Nov 2023 | |
| Desegregate CT — General Support | Desegregate CT | $425K | Nov 2021 | |
| Center on Budget and Policy Priorities — Full Employment Project (2016) | Center On Budget And Policy Priorities | $425K | Jul 2016 | |
| Rethink Priorities — Global Health and Wellbeing Cause Research | Rethink Priorities | $419K | Apr 2021 | |
| Data for Decisions — Syphilis Vaccine Economic Research | Data For Decisions | $415K | Dec 2022 | |
| Greater Greater Washington — Housing and Land Use Reform (2023) | Greater Greater Washington | $406K | Oct 2023 | |
| Organisation for Economic Co-operation and Development — Non-compete Prevalence Survey | Organisation For Economic Co Operation And Development | $405K | Jun 2024 | |
| California Renters Legal Advocacy and Education Fund — General Support (2021) | CalHDF | $400K | Dec 2021 | |
| Yale University — Cardiovascular Research | Yale University | $400K | Dec 2022 | |
| Sightline Institute — Housing and Urban Development | Sightline Institute | $400K | Oct 2015 | |
| OliLux Biosciences — Rapid Tuberculosis Detection and Treatment Management Tools | OliLux Biosciences | $400K | Jan 2021 | |
| Peterson Institute for International Economics — Macroeconomic Research Projects | Peterson Institute For International Economics | $400K | Jan 2019 | |
| Niskanen Center — Research on Immigration Policy (2018) | Niskanen Center | $400K | Jan 2018 | |
| Effective Altruism Foundation — European Policy Research and Advocacy (2020) | Effective Altruism Foundation | $375K | Oct 2020 | |
| MoveOn Civic Action — Syrian Refugee Advocacy | MoveOn.Org Civic Action | $375K | Oct 2015 | |
| New Incentives — Exit Grant and Immunizations Pilot | New Incentives | $369K | Nov 2016 | |
| Urban Institute — History of Philanthropy Project | Urban Institute | $366K | Dec 2017 | |
| Niskanen Center — Research on Immigration Policy | Niskanen Center | $360K | Oct 2015 | |
| Yale University — Malaria Vaccine Research (Richard Bucala) | Yale University | $360K | Jun 2021 | |
| World Health Organization – Next-Generation Malaria Vaccines | World Health Organization | $359K | Oct 2024 | |
| University of Edinburgh — Syphilis Genome Sequencing | University of Edinburgh | $358K | Jun 2023 | |
| Charity Science Health — SMS Reminders for Immunization | Charity Science Health | $358K | Jul 2017 | |
| University of Washington — HCV Vaccine Research | University of Washington | $356K | Oct 2023 | |
| Innovations for Poverty Action — Mindset Engagement in Cash Transfers | Innovations for Poverty Action | $350K | May 2016 | |
| P150 — General Support (2024) | P150 | $350K | Dec 2023 | |
| Stanford University — Immunization Research | Stanford University | $350K | Dec 2021 | |
| WaitList Zero — General Support (2019) | WaitList Zero | $350K | Dec 2019 | |
| California YIMBY — General Support (August 2018) | California YIMBY | $350K | Aug 2018 | |
| Sightline Institute — Housing and Urban Development (2017) | Sightline Institute | $350K | Oct 2017 | |
| California Renters Legal Advocacy and Education Fund — General Support (2019) | CalHDF | $340K | Feb 2019 | |
| IRD Global — Zero TB Program | IRD Global | $336K | Jun 2021 | |
| Center on Budget and Policy Priorities — Full Employment Project (2014) | Center On Budget And Policy Priorities | $335K | Sep 2014 | |
| Princeton University — Research on Hepatitis B Variant | Princeton University | $330K | Oct 2023 | |
| Rita Allen Foundation — Award in Pain Scholars | Rita Allen Foundation | $330K | Jul 2020 | |
| Agricultural Research Service — Malaria Control Research (2021) | Agricultural Research Service | $321K | Aug 2021 | |
| Evidence Action Beta — Iron and Folic Acid Supplementation | Evidence Action | $320K | Jun 2018 | |
| Yale University — Helminth Vaccine Research | Yale University | $316K | Aug 2022 | |
| IDinsight — Embedded GiveWell Team | IDinsight | $315K | Nov 2016 | |
| Cornell University — National Zoning Atlas | Cornell University | $312K | Jun 2022 | |
| Center for Popular Democracy Action Fund — Fed Up Campaign (2017) | Center For Popular Democracy Action Fund | $305K | Feb 2017 | |
| New Incentives — General Support (2016) | New Incentives | $300K | Mar 2016 | |
| Probably Good — General Support | Probably Good | $300K | Feb 2022 | |
| YIMBY Action – Housing Advocacy in Los Angeles | YIMBY Action | $300K | Jun 2022 | |
| Center for Global Development — General Support | Center for Global Development | $300K | Jul 2013 | |
| Greater Greater Washington — Housing and Land Use Reform (2019) | Greater Greater Washington | $300K | Aug 2019 | |
| Employ America — General Support (April 2019) | Employ America | $300K | Apr 2019 | |
| California Renters Legal Advocacy and Education Fund — General Support | CalHDF | $300K | Jun 2016 | |
| Fortify Health — General Support | Fortify Health | $295K | Jun 2018 | |
| ImmigrationWorks Foundation — General Support | ImmigrationWorks Foundation | $285K | Jul 2014 | |
| University of Washington — Syphilis Vaccine Development (David Baker and Neil King) | University of Washington | $284K | Dec 2021 | |
| Yale University — Migration Research in Nepal | Yale University | $277K | Jan 2022 | |
| Direct Relief — COVID-19 Action Fund for Africa | Direct Relief | $275K | Oct 2020 | |
| Smart Growth America — Greater Greater Washington Education Project | Smart Growth America | $275K | Jul 2015 | |
| One for the World — General Support (2021) | One for the World | $261K | May 2021 | |
| Yale University — Malaria Vaccine Research (2022) | Yale University | $257K | Sep 2022 | |
| Evidence Action — Planning for Future Programs | Evidence Action | $250K | Mar 2014 | |
| Living Goods — General Support (January 2017) | Living Goods | $250K | Jan 2017 | |
| Project Healthy Children — General Support (January 2017) | Project Healthy Children | $250K | Jan 2017 | |
| Global Alliance for Improved Nutrition — Universal Salt Iodization (January 2017) | Global Alliance For Improved Nutrition | $250K | Jan 2017 | |
| Food Fortification Initiative — General Support (December 2016) | Food Fortification Initiative | $250K | Dec 2016 | |
| Peterson Institute for International Economics — Macroeconomic Stabilization | Peterson Institute For International Economics | $250K | Apr 2016 | |
| Iodine Global Network — General Support (December 2016) | Iodine Global Network | $250K | Dec 2016 | |
| Development Media International — General Support (December 2016) | Development Media International | $250K | Dec 2016 | |
| Schistosomiasis Control Initiative — General Support (2012) | Schistosomiasis Control Initiative | $250K | Dec 2012 | |
| Georgetown University — Public Health and Cannabis Legalization | Georgetown University | $250K | Aug 2015 | |
| Deworm the World Initiative — General Support (December 2014) | Evidence Action | $250K | Dec 2014 | |
| Iodine Global Network — General Support (December 2015) | Iodine Global Network | $250K | Dec 2015 | |
| Development Media International — General Support (December 2014) | Development Media International | $250K | Dec 2014 | |
| Living Goods — General Support (December 2015) | Living Goods | $250K | Dec 2015 | |
| Iodine Global Network — General Support (December 2014) | Iodine Global Network | $250K | Dec 2014 | |
| Living Goods — General Support (December 2014) | Living Goods | $250K | Dec 2014 | |
| Global Alliance for Improved Nutrition — General Support (October 2015) | Global Alliance For Improved Nutrition | $250K | Oct 2015 | |
| Development Media International — General Support (December 2015) | Development Media International | $250K | Dec 2015 | |
| Global Alliance for Improved Nutrition — General Support (December 2014) | Global Alliance For Improved Nutrition | $250K | Dec 2014 | |
| Greater Greater Washington — Housing and Land Use Reform (2017) | Greater Greater Washington | $250K | Jun 2017 | |
| Center on Budget and Policy Priorities — Full Employment Project (2018) | Center On Budget And Policy Priorities | $250K | Jul 2018 | |
| Foundation for Professional Development Fund — Syphilis Genome Sequencing | Foundation For Professional Development Fund | $229K | Dec 2022 | |
| Princeton University — Transgenic Mice for Hepatitis B Research | Princeton University | $220K | Oct 2023 | |
| FairVote Washington — Ranked Choice Voting Adoption | FairVote Washington | $217K | Dec 2021 | |
| Charity Science Health — Exit Grant | Charity Science Health | $214K | Dec 2019 | |
| Dezernat Zukunft — Monetary and Fiscal Policy in Europe (2020) | Dezernat Zukunft | $202K | Nov 2020 | |
| J-PAL — Support for Immunization Incentives RCTs | Abdul Latif Jameel Poverty Action Lab | $200K | Sep 2015 | |
| Charity Science: Health — General Support | Charity Science Health | $200K | Nov 2016 | |
| WaitList Zero — General Support | WaitList Zero | $200K | Aug 2015 | |
| Roosevelt Institute — Macroeconomic Policy Research | Roosevelt Institute | $200K | Jun 2016 | |
| California YIMBY — Ballot Initiative Scoping Grant | California YIMBY | $200K | Aug 2022 | |
| University of Texas Medical Branch — Nucleic Acid Antiviral Testing | University Of Texas Medical Branch | $200K | Jun 2023 | |
| World Heart Federation — Rheumatic Heart Disease Congress | World Heart Federation | $200K | Mar 2023 | |
| Niskanen Center — Research on Immigration Policy (2020) | Niskanen Center | $200K | Jan 2020 | |
| University of Georgia — Malaria Research (2023) | University Of Georgia | $193K | Jan 2023 | |
| Project Peanut Butter — Ready-to-Use Therapeutic Food Standards | Project Peanut Butter | $191K | Feb 2022 | |
| Stanford University — Ethical Protections for Potential Tuberculosis Vaccine Trial | Stanford University | $188K | Feb 2024 | |
| Fair Share Housing Center — Legal Work in NJ | Fair Share Housing Center | $185K | May 2023 | |
| IDinsight — New Incentives RCT | IDinsight | $184K | Mar 2019 | |
| YIMBY Law — General Support (2024) | YIMBY Law | $180K | Jun 2024 | |
| Yale University School of Medicine — Vascular Therapy Research | Yale University | $180K | Mar 2019 | |
| Williams College — Regulatory Affairs Position | Williams College | $176K | Mar 2024 | |
| Desegregate CT — Exit Grant | Desegregate CT | $175K | Oct 2023 | |
| Evidence Action — Seasonal Income Support Project | Evidence Action | $171K | Mar 2015 | |
| UC Berkeley — Deworming and Cash Transfers (2019) | University of California, Berkeley | $170K | Feb 2019 | |
| International Initiative for Impact Evaluation — Follow-up of Mozambique Preschool Trial | International Initiative For Impact Evaluation | $170K | Mar 2025 | |
| Yale University — Regulatory Affairs Fellowship | Yale University | $167K | Aug 2022 | |
| Fiocruz — Ethical Protections for Potential Tuberculosis Vaccine Trial | Fiocruz | $166K | Nov 2023 | |
| University of Southern California — Linezolid Trial for Syphilis | University of Southern California | $160K | Oct 2023 | |
| One for the World — General Support (2018) | One for the World | $154K | Jul 2018 | |
| Rutgers University — Ethical Protections for Potential Tuberculosis Vaccine Trial | Rutgers University | $150K | Nov 2023 | |
| Pepperdine University — Washington THC Monitoring | Pepperdine University | $150K | Jun 2014 | |
| Abundant Housing LA — General Support | Abundant Housing LA | $150K | May 2021 | |
| ImmigrationWorks Foundation — General Support 2016 | ImmigrationWorks Foundation | $150K | Dec 2015 | |
| Sightline Institute – Housing and Urban Development (February 2019) | Sightline Institute | $150K | Feb 2019 | |
| Coalition for Global Hepatitis Elimination — Hepatitis B Treatment | Coalition For Global Hepatitis Elimination | $140K | Oct 2022 | |
| International Vaccine Institute — Schistosomiasis Vaccine Assessment | International Vaccine Institute | $140K | Aug 2021 | |
| Columbia University — Regulatory Affairs Position | Columbia University | $139K | Jun 2023 | |
| Positive Money Europe — European Macro Policy | Positive Money Europe | $136K | Jan 2022 | |
| YIMBY Action — Housing Advocacy in California (2024) | YIMBY Action | $120K | Jun 2024 | |
| Rethink Priorities — Research Assistant and Expenses | Rethink Priorities | $120K | Jul 2022 | |
| Sightsavers — Scoping Work on Deworming Programs | Sightsavers | $118K | Feb 2022 | |
| University of Southern California — Preterm Births Research | University of Southern California | $114K | Mar 2023 | |
| Georgia Institute of Technology — Portable Spectrometers | Georgia Institute of Technology | $111K | Oct 2022 | |
| RAND Corporation — Research for Vermont | RAND | $103K | Aug 2014 | |
| gui2de — Zusha! Road Safety Campaign (December 2018) | Georgetown University | $100K | Dec 2018 | |
| Living Goods — General Support (January 2019) | Living Goods | $100K | Jan 2019 | |
| Iodine Global Network — General Support (January 2019) | Iodine Global Network | $100K | Jan 2019 | |
| Global Alliance for Improved Nutrition — Universal Salt Iodization (December 2018) | Global Alliance For Improved Nutrition | $100K | Dec 2018 | |
| Evidence Action — Dispensers for Safe Water Program (2018) | Evidence Action | $100K | Dec 2018 | |
| Global Alliance for Improved Nutrition — Universal Salt Iodization (December 2017) | Global Alliance For Improved Nutrition | $100K | Dec 2017 | |
| Living Goods — General Support (January 2018) | Living Goods | $100K | Jan 2018 | |
| Development Media International — General Support (December 2018) | Development Media International | $100K | Dec 2018 | |
| Project Healthy Children — General Support (December 2017) | Project Healthy Children | $100K | Dec 2017 | |
| Iodine Global Network — General Support (December 2017) | Iodine Global Network | $100K | Dec 2017 | |
| Evidence Action — Dispensers for Safe Water Program (2017) | Evidence Action | $100K | Dec 2017 | |
| Project Healthy Children — General Support (December 2018) | Project Healthy Children | $100K | Dec 2018 | |
| New Incentives — General Support (2014) | New Incentives | $100K | Jan 2014 | |
| Food Fortification Initiative — General Support (December 2018) | Food Fortification Initiative | $100K | Dec 2018 | |
| Food Fortification Initiative — General Support (December 2017) | Food Fortification Initiative | $100K | Dec 2017 | |
| Development Media International — General Support (December 2017) | Development Media International | $100K | Dec 2017 | |
| Carnegie Endowment for International Peace — Work on India and China | Carnegie Endowment for International Peace | $100K | Mar 2015 | |
| gui2de — Zusha! Road Safety Exit Grant | Georgetown University | $100K | Oct 2021 | |
| gui2de — Zusha! Road Safety Campaign (February 2020) | Georgetown University | $100K | Feb 2020 | |
| Food Fortification Initiative — General Support (December 2019) | Food Fortification Initiative | $100K | Dec 2019 | |
| Harvard University — Political Polarization App | Harvard University | $100K | Mar 2023 | |
| Food Fortification Initiative — Exit Grant | Food Fortification Initiative | $100K | Oct 2021 | |
| Project Healthy Children — General Support (December 2019) | Project Healthy Children | $100K | Dec 2019 | |
| Development Media International — General Support (January 2020) | Development Media International | $100K | Jan 2020 | |
| Global Alliance for Improved Nutrition — Exit Grant | Global Alliance For Improved Nutrition | $100K | Oct 2021 | |
| Iodine Global Network — Exit Grant | Iodine Global Network | $100K | Sep 2021 | |
| Development Media International — Exit Grant | Development Media International | $100K | Oct 2021 | |
| Project Healthy Children — Exit Grant | Project Healthy Children | $100K | Sep 2021 | |
| Living Goods — Exit Grant | Living Goods | $100K | Oct 2021 | |
| Global Alliance for Improved Nutrition — Universal Salt Iodization (January 2020) | Global Alliance For Improved Nutrition | $100K | Jan 2020 | |
| Solar Cooling Engineering — Solar Refrigerator Testing | Solar Cooling Engineering | $100K | Oct 2021 | |
| Vital Strategies — Support for a Consortium on Alcohol Control Policy | Vital Strategies | $100K | Jan 2021 | |
| Living Goods — General Support (January 2020) | Living Goods | $100K | Jan 2020 | |
| Precision Development — Exit Grant | Precision Development | $100K | Sep 2021 | |
| Gordon Research Conferences — Malaria Conference 2025 | Gordon Research Conferences | $100K | Feb 2025 | |
| Evidence Action — Dispensers for Safe Water Program (2019) | Evidence Action | $100K | Dec 2019 | |
| Iodine Global Network — General Support (December 2019) | Iodine Global Network | $100K | Dec 2019 | |
| The College of William and Mary — Uganda Smartphone RCT | College Of William And Mary | $100K | May 2022 | |
| Evidence Action — Dispensers for Safe Water Exit Grant | Evidence Action | $100K | Oct 2021 | |
| Brookings Institution – Work on China and India | Brookings Institution | $100K | Jun 2015 | |
| Center for Global Development — Impact Evaluation Case Studies | Center for Global Development | $100K | Oct 2019 | |
| US Cochrane Center — General Support | United States Cochrane Center | $100K | Jul 2012 | |
| New Incentives — General Support (2015) | New Incentives | $100K | Mar 2015 | |
| Center for Popular Democracy — Federal Reserve Campaign (2014) | Center For Popular Democracy | $100K | Aug 2014 | |
| Dezernat Zukunft — Monetary and Fiscal Policy in Europe (2019) | Dezernat Zukunft | $100K | Dec 2019 | |
| Washington Center for Equitable Growth — Automatic Stabilizers Conference | Washington Center For Equitable Growth | $100K | Oct 2018 | |
| Center on Budget and Policy Priorities — Automatic Stabilizers | Center On Budget And Policy Priorities | $100K | May 2018 | |
| Center for Popular Democracy Action Fund — Fed Up Campaign (2018) | Center For Popular Democracy Action Fund | $100K | Feb 2018 | |
| WaitList Zero — General Support (January 2018) | WaitList Zero | $100K | Jan 2018 | |
| YIMBY Law — General Support (January 2020) | YIMBY Law | $100K | Jan 2020 | |
| UC Berkeley — In-Line Water Chlorination Devices (Amy Pickering) (2020) | University of California, Berkeley | $99K | Oct 2020 | |
| Urban Institute — Land Use Convening | Urban Institute | $98K | Sep 2015 | |
| University of Southern California — Syphilis Genome Sequencing | University of Southern California | $90K | Dec 2022 | |
| Botswana-Harvard AIDS Institute – Early detection of preterm births | Botswana Harvard AIDS Institute | $90K | Oct 2021 | |
| UC Berkeley — Deworming and Cash Transfers (2020) | University of California, Berkeley | $88K | Mar 2020 | |
| UC Berkeley — Tuberculosis Research | University of California, Berkeley | $85K | Aug 2022 | |
| Abundant Housing LA — Lawmaker Engagement | Abundant Housing LA | $80K | Jan 2022 | |
| Positive Money Europe — Exit Grant | Positive Money Europe | $77K | Apr 2024 | |
| AURA — YIMBYTown (2024) | AURA | $75K | Sep 2023 | |
| National Academy of Sciences — Future of Biomedical Databases Study | National Academy Of Sciences | $75K | Dec 2024 | |
| Terner Housing Innovation Labs — Housing Policy Dashboard | Terner Housing Innovation Labs | $75K | Feb 2023 | |
| International Refugee Assistance Project — Family Reunification | International Refugee Assistance Project | $75K | May 2019 | |
| Positive Money Europe — Macroeconomic Policy Research and Advocacy | Positive Money Europe | $73K | Jan 2021 | |
| Dalberg Advisors – R&D Portfolio Analysis | Dalberg Advisors | $73K | Jul 2022 | |
| Ifakara Health Institute — Malaria Vaccine Clinical Trial (Ally Olotu) | Ifakara Health Institute | $68K | Jul 2021 | |
| WAW Statistical Consulting Ltd — R Package for Bayesian Evidence Aggregation | WAW Statistical Consulting Ltd | $66K | Apr 2022 | |
| UC Berkeley — Tuberculosis Diagnosis (Adithya Cattamanchi and Sarah Stanley) | University of California, Berkeley | $60K | Jul 2021 | |
| Zipline — Scoping Grant for Vaccine Delivery | Zipline | $55K | Jan 2025 | |
| Seattle for Everyone — General Support | Seattle For Everyone | $50K | Feb 2016 | |
| gui2de — Zusha! Road Safety Campaign (December 2020) | Georgetown University | $50K | Dec 2020 | |
| UC Berkeley — Research on Labor Market Outcomes | University of California, Berkeley | $50K | Nov 2021 | |
| Development Media International — General Support (December 2020) | Development Media International | $50K | Dec 2020 | |
| Evidence Action — Dispensers for Safe Water Program (December 2020) | Evidence Action | $50K | Dec 2020 | |
| Living Goods — General Support (December 2020) | Living Goods | $50K | Dec 2020 | |
| Kansas State University — Fungal Genetics Stock Center | Kansas State University | $50K | Jul 2021 | |
| Food Fortification Initiative — General Support (December 2020) | Food Fortification Initiative | $50K | Dec 2020 | |
| Project Healthy Children — General Support (December 2020) | Project Healthy Children | $50K | Dec 2020 | |
| Global Alliance for Improved Nutrition — Universal Salt Iodization (January 2021) | Global Alliance For Improved Nutrition | $50K | Feb 2021 | |
| Sightline Institute — YIMBYtown (2022) | Sightline Institute | $50K | May 2022 | |
| Iodine Global Network — General Support (December 2020) | Iodine Global Network | $50K | Dec 2020 | |
| Waitlist Zero — Planning Grant | WaitList Zero | $50K | Sep 2014 | |
| Center for Global Development — Malaria Reduction | Center for Global Development | $50K | Jun 2021 | |
| Update to Millions Saved Project | Center for Global Development | $50K | Jun 2013 | |
| Center for Global Development — Aid Effectiveness Advocacy Research | Center for Global Development | $50K | Dec 2020 | |
| Urban Institute — Countercyclical State Funding Mechanisms | Urban Institute | $50K | Nov 2020 | |
| Georgetown University — Center on Poverty and Inequality | The Center On Poverty And Inequality | $50K | Jan 2020 | |
| Protect the People — Exit Grant | Protect The People | $50K | Oct 2016 | |
| Sightline Institute — YIMBYtown (2019) | Sightline Institute | $50K | Jun 2019 | |
| American University of Beirut — STI Diagnostic | American University Of Beirut | $49K | Apr 2023 | |
| University of Michigan — Support for David Manley | University of Michigan | $47K | Oct 2018 | |
| Nova School of Business and Economics — Study on Development Interventions | Nova School Of Business And Economics | $45K | Jan 2025 | |
| International Rescue Committee – Treatment of Malnutrition (October 2021) | International Rescue Committee | $42K | Oct 2021 | |
| Harborlight Community Partners — YIMBYtown 2018 Conference | Harborlight Community Partners | $40K | Mar 2018 | |
| East Bay Forward — YIMBYtown 2017 Conference | East Bay Forward | $40K | Apr 2017 | |
| Better Boulder — YIMBY 2016 | Better Boulder | $37K | Apr 2016 | |
| IDinsight — Scaling Up a High-Potential Development Intervention | IDinsight | $34K | Sep 2014 | |
| Center for Popular Democracy Action Fund — Fed Up Campaign (October 2016) | Center For Popular Democracy Action Fund | $32K | Oct 2016 | |
| New York University — Support for a Labor Mobility RCT | New York University | $30K | Aug 2015 | |
| RAND Corporation — Study Planning | RAND | $25K | Feb 2022 | |
| Rockefeller Archive Center: Workshop on the History of Philanthropy | Rockefeller Archive Center | $25K | Aug 2014 | |
| Free Migration Project — Planning Grant | Free Migration Project | $24K | May 2016 | |
| Stanford Existential Risks Initiative — Distribution of The Precipice | Stanford Existential Risks Initiative | $24K | May 2021 | |
| University of Warwick — Evidence-Based Policymaking | University of Warwick | $21K | Nov 2024 | |
| UC Berkeley — Fieldwork Trip for Proposed RCT | University of California, Berkeley | $20K | Feb 2025 | |
| Center for Effective Global Action at UC Berkeley — Deworming Study Planning Gift | University of California, Berkeley | $18K | Jun 2017 | |
| Effective Altruism Foundation — European Policy Research | Effective Altruism Foundation | $15K | Apr 2020 | |
| Instituto Tecnológico Autónomo de México — Lead Exposure Investigation | Instituto TecnolóGico AutóNomo De MéXico | $13K | Jun 2023 | |
| IDinsight — Moral Weights Survey Planning | IDinsight | $12K | May 2022 | |
| iGEM — Support for Team ABSI_Kenya’s Project | International Genetically Engineered Machine Foundation | $8.5K | May 2021 | |
| ARNOVA — History of Philanthropy Prize | ARNOVA | $2K | Aug 2015 | |