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1Day Sooner - Wikipedia
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Tangentially relevant to AI safety through biosecurity and pandemic preparedness angles; 1Day Sooner's model of accelerating medical countermeasures is sometimes cited in discussions about responding to biological risks, including those potentially exacerbated by AI capabilities.
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Summary
1Day Sooner is a nonprofit organization that advocates for human challenge trials in medical research, where volunteers are intentionally exposed to pathogens to accelerate vaccine and treatment development. The organization gained prominence during COVID-19 by recruiting volunteers willing to participate in challenge trials to speed up vaccine testing. Their work intersects with biosafety, pandemic preparedness, and ethical frameworks around accelerating medical countermeasures.
Key Points
- •1Day Sooner recruits and advocates for volunteers willing to participate in human challenge trials to accelerate medical research timelines
- •The organization became prominent during COVID-19, arguing challenge trials could shave months off vaccine development and save lives
- •Raises important ethical questions about informed consent, acceptable risk, and utilitarian tradeoffs in medical research
- •Relevant to biosecurity and pandemic preparedness discussions, including how to rapidly develop countermeasures against engineered or natural pathogens
- •Demonstrates how altruistic volunteer networks can potentially accelerate responses to biological threats
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| Page | Type | Quality |
|---|---|---|
| 1Day Sooner | Organization | 60.0 |
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1Day Sooner - Wikipedia
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Public health nonprofit
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1Day Sooner Founded March 2020 [ 1 ] Type Nonprofit organization Focus Human challenge studies, Covid-19, public health policy Key people Joshua Morrison (Founder) Website 1daysooner .org
1Day Sooner is a nonprofit that advocates for people who want to participate in medical research, in particular human challenge trials. [ 2 ] 1Day Sooner began in March 2020 in response to the COVID-19 pandemic , organizing people willing to volunteer in human challenge trials as a means to speed development of vaccines against the disease. 1Day Sooner's advocacy for COVID-19 challenge trials was met with both support and opposition among the public, scientists, and bioethicists . COVID-19 challenge trials were ultimately implemented in the United Kingdom.
1Day Sooner also conducts advocacy work on public health policy and for challenge trials in other infectious diseases.
Covid-19 challenge trials
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1Day Sooner was established by Josh Morrison, a founder of kidney donation group Waitlist Zero , and Sophie Rose, a Stanford biology graduate. [ 3 ] [ 4 ] Morrison and Rose were motivated to do so after reading about how human challenge trials in young, healthy volunteers could potentially accelerate COVID-19 vaccine development , and set up an initial signup website in March 2020 for people interested in being a research subject in COVID-19 human challenge studies . [ 4 ] [ 5 ] [ 3 ]
By October 2020, over 38,500 had expressed interest in participation via the website. [ 6 ] [ 7 ]
A survey study of 1Day Sooner prospective volunteers found that they were more likely to display altruistic behaviors, such as charitable donations or blood donation, than a control group. The study argued that this potentially addressed concerns of some bioethicists regarding the potential exploitation of volunteers. [ 8 ] [ 9 ]
1Day Sooner viewed challenge trials as a means to promote the development of multiple vaccines, particularly ones accessible in low-income countries , as well as gain more insight into COVID-19 immunity. [ 10 ] [ 11 ] If early vaccine candidates in development in 2020 had turned out to be ineffective, moreover, 1Day Sooner argued challenge trials could have been used to prioritize most promising vaccines from remaining candidates. [ 12 ] The organization held that if challenge trials could result in a benefit for society, informed individuals should be allowed the freedom to volunteer themselves, even in the face of potentially seri
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