| Helen Keller International — Vitamin A Supplementation (January 2023)source | Coefficient Giving | Helen Keller International | | $67M | 2023-01 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (2023)source | Coefficient Giving | Malaria Consortium | | $61M | 2023-03 | |
| Georgetown University — Center for Security and Emerging Technologysource | Coefficient Giving | CSET (Center for Security and Emerging Technology) | | $55M | 2019-01 | |
| Just Impact — Safely Reducing Incarcerationsource | Coefficient Giving | Just Impact | | $53M | 2021-12 | |
| Evidence Action — Dispensers for Safe Water Program (February 2022)source | Coefficient Giving | Evidence Action | | $49M | 2022-02 | |
| Gates Philanthropy Partners — Tuberculosis Vaccine Candidatesource | Coefficient Giving | Gates Philanthropy Partners | | $40M | 2023-02 | |
| Center for Security and Emerging Technology — General Support (August 2021)source | Coefficient Giving | CSET (Center for Security and Emerging Technology) | | $39M | 2021-08 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (February 2020)source | Coefficient Giving | Malaria Consortium | | $34M | 2020-02 | |
| Evidence Action — Scale-Up of In-Line Chlorination in Indiasource | Coefficient Giving | Evidence Action | | $33M | 2024-01 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (2022)source | Coefficient Giving | Malaria Consortium | | $32M | 2022-03 | |
| OpenAI — General Supportsource | Coefficient Giving | 252 | | $30M | 2017-03 | |
| FAR.AI — AI Safety Research and Field-buildingsource | Coefficient Giving | FAR AI | | $29M | 2025-09 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (December 2017)source | Coefficient Giving | Malaria Consortium | | $28M | 2017-12 | |
| Development Innovation Ventures — Scaling Up Global Health Interventionssource | Coefficient Giving | Development Innovation Ventures | | $28M | 2023-01 | |
| Malaria Consortium — Support for LLIN Distribution Campaignssource | Coefficient Giving | Malaria Consortium | | $27M | 2021-04 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (December 2020)source | Coefficient Giving | Malaria Consortium | | $27M | 2020-12 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (December 2018)source | Coefficient Giving | Malaria Consortium | | $27M | 2018-12 | |
| Centre for Effective Altruism — General Support (2022)source | Coefficient Giving | Centre for Effective Altruism | | $26M | 2022-03 | |
| BlueDot Impact — General Support (2025)source | Coefficient Giving | BlueDot Impact | | $26M | 2025-06 | |
| Eleanor Crook Foundation — Global Malnutrition Regrantingsource | Coefficient Giving | Eleanor Crook Foundation | | $25M | 2023-03 | |
| IRD Global — Mobile Conditional Cash Transfers for Immunizationssource | Coefficient Giving | IRD Global | | $25M | 2021-10 | |
| Gates Philanthropy Partners — Oral Cholera Vaccine Productionsource | Coefficient Giving | Gates Philanthropy Partners | | $25M | 2023-02 | |
| GiveDirectly — General Support (June 2015)source | Coefficient Giving | GiveDirectly | | $25M | 2015-06 | |
| MATS Research — General Supportsource | Coefficient Giving | MATS ML Alignment Theory Scholars program | | $24M | 2025-05 | |
| Effective Ventures Foundation — Event Venuesource | Coefficient Giving | Centre for Effective Altruism | | $23M | 2021-12 | |
| Centre for Effective Altruism — General Support (EVF, May 2024)source | Coefficient Giving | Centre for Effective Altruism | | $23M | 2024-05 | |
| Against Malaria Foundation — General Support (January 2016)source | Coefficient Giving | Against Malaria Foundation | | $23M | 2016-01 | |
| Against Malaria Foundation — Insecticide-Treated Bednetssource | Coefficient Giving | Against Malaria Foundation | | $22M | 2024-06 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention Programs (2021)source | Coefficient Giving | Malaria Consortium | | $22M | 2021-03 | |
| Johns Hopkins Center for Health Security — Biosecurity, Global Health Security, and Global Catastrophic Risks (2019)source | Coefficient Giving | Johns Hopkins Center for Health Security | | $20M | 2019-09 | |
| LEAF — Lead Exposure Reductionsource | Coefficient Giving | Lead Exposure Action Fund | | $20M | 2024-09 | |
| Unlimit Health — Deworming and Worm Burden Mapping (2022)source | Coefficient Giving | Unlimit Health | | $20M | 2022-01 | |
| International Rescue Committee – Treatment of Malnutrition (May to August 2021)source | Coefficient Giving | International Rescue Committee | | $20M | 2021-05 | |
| Sherlock Biosciences — Research on Viral Diagnosticssource | Coefficient Giving | Sherlock Biosciences | | $18M | 2019-01 | |
| Target Malaria — Gene Drives for Malaria Controlsource | Coefficient Giving | Target Malaria | | $18M | 2017-05 | |
| New Incentives — General Support (2021)source | Coefficient Giving | New Incentives | | $17M | 2021-01 | |
| Constellation — Programmatic Activities and Operating Expensessource | Coefficient Giving | Constellation | | $17M | 2024-06 | |
| RAND Corporation — Biosecurity Policysource | Coefficient Giving | RAND | | $17M | 2023-05 | |
| Johns Hopkins Center for Health Security — Biosecurity, Global Health Security, and Global Catastrophic Risks (2017)source | Coefficient Giving | Johns Hopkins Center for Health Security | | $16M | 2017-01 | |
| Longview Philanthropy — General Support (October 2024)source | Coefficient Giving | Longview Philanthropy | | $16M | 2024-10 | |
| Malaria Consortium — Seasonal Malaria Chemoprevention in Mozambique (2022)source | Coefficient Giving | Malaria Consortium | | $16M | 2022-02 | |
| Malaria Consortium — Support for SMC in FCT and Oyo States, Nigeriasource | Coefficient Giving | Malaria Consortium | | $16M | 2021-10 | |
| Deworm the World Initiative — General Support (December 2017)source | Coefficient Giving | Evidence Action | | $15M | 2017-12 | |
| Against Malaria Foundation — General Support (January 2017)source | Coefficient Giving | Against Malaria Foundation | | $15M | 2017-01 | |
| Vital Strategies — RESET Alcohol Initiativesource | Coefficient Giving | Vital Strategies | | $15M | 2022-01 | |
| Grant to "support Longview’s independent grantmaking on global priorities research, nuclear weapons policy, and other longtermist issues."source | FTX Future Fund | Longview Philanthropy | | $15M | 2022-02 | |
| Evidence Action — Accelerator Programsource | Coefficient Giving | Evidence Action | | $14M | 2022-01 | |
| Grant for "general support for their activities, including running conferences, supporting student groups, and maintaining online resources."source | FTX Future Fund | Centre for Effective Altruism | | $14M | 2022-03 | |
| New Incentives – Conditional Cash Transfers in Nigeriasource | Coefficient Giving | New Incentives | | $14M | 2022-06 | |
| Schistosomiasis Control Initiative — General Support (2017)source | Coefficient Giving | Schistosomiasis Control Initiative | | $14M | 2017-01 | |
| Massachusetts Institute of Technology — AI Trends and Impacts Research (2022)source | Coefficient Giving | Massachusetts Institute of Technology | | $13M | 2022-03 | |
| Anima International — General Supportsource | Coefficient Giving | Anima International | | $13M | 2023-10 | |
| Evidence Action — Syphilis Screening and Treatmentsource | Coefficient Giving | Evidence Action | | $13M | 2022-08 | |
| Centre for Pesticide Suicide Prevention — General Support (2024)source | Coefficient Giving | Centre for Pesticide Suicide Prevention | | $13M | 2024-06 | |
| Mercy for Animals — Corporate Campaigns (2022)source | Coefficient Giving | Mercy For Animals | | $12M | 2022-08 | |
| Mercy for Animals — Corporate Campaigns (2024)source | Coefficient Giving | Mercy For Animals | | $12M | 2024-07 | |
| Future of Humanity Institute — Work on Global Catastrophic Riskssource | Coefficient Giving | Future of Humanity Institute | | $12M | 2018-07 | |
| FAR AI — AI Safety Regrantingsource | Coefficient Giving | FAR AI | | $12M | 2024-06 | |
| UC Berkeley — Center for Human-Compatible Artificial Intelligence (2021)source | Coefficient Giving | University of California, Berkeley | | $12M | 2021-01 | |
| Institute for AI Policy and Strategy — General Support (2025)source | Coefficient Giving | Institute for AI Policy and Strategy | | $12M | 2025-04 | |
| Evidence Action — No Lean Season (December 2017)source | Coefficient Giving | Evidence Action | | $12M | 2017-12 | |
| Effective Ventures Foundation — General Supportsource | Coefficient Giving | Centre for Effective Altruism | | $11M | 2022-12 | |
| University of Washington — Universal Flu Vaccine and Computational Protein Design (David Baker and Neil King)source | Coefficient Giving | University of Washington (Institute for Protein Design) | | $11M | 2017-11 | |
| Sightsavers — Deworming Programs (2023)source | Coefficient Giving | Sightsavers | | $11M | 2023-03 | |
| Californians Against Pandemics — California Pandemic Early Detection and Prevention Act Ballot Initiativesource | Coefficient Giving | Californians Against Pandemics | | $11M | 2021-10 | |
| Centre for Effective Altruism — General Support (EVF, June 2023)source | Coefficient Giving | Centre for Effective Altruism | | $11M | 2023-06 | |
| OpenMined Foundation — Secure Enclaves for LLM Evaluationsource | Coefficient Giving | OpenMined | | $11M | 2025-06 | |
| Deworm the World Initiative — General Support (January 2016)source | Coefficient Giving | Evidence Action | | $11M | 2016-01 | |
| Redwood Research — General Support (2022)source | Coefficient Giving | Redwood Research | | $11M | 2022-08 | |
| RAND Corporation — Emerging Technology Initiativessource | Coefficient Giving | RAND | | $11M | 2023-10 | |
| Clinton Health Access Initiative – CHAI Incubatorsource | Coefficient Giving | Clinton Health Access Initiative | | $10M | 2022-09 | |
| Deworm the World Initiative — General Support (December 2018)source | Coefficient Giving | Evidence Action | | $10M | 2018-12 | |
| Accountability Board — Advocacy Campaignssource | Coefficient Giving | The Accountability Board | | $10M | 2022-08 | |
| UC Davis — Malaria Gene Drive Feasibility Analysis (Greg Lanzaro) (2021)source | Coefficient Giving | University of California, Davis | | $10M | 2021-12 | |
| Forecasting Research Institute — General Supportsource | Coefficient Giving | Forecasting Research Institute (FRI) | | $10M | 2025-02 | |
| Vital Strategies — RESET Alcohol Initiative (2024)source | Coefficient Giving | Vital Strategies | | $10M | 2024-11 | |
| Johns Hopkins Center for Health Security — Biosecurity, Global Health Security, and Global Catastrophic Risks (2023)source | Coefficient Giving | Johns Hopkins Center for Health Security | | $10M | 2023-03 | |
| The Humane League — General Support (2025)source | Coefficient Giving | The Humane League | | $10M | 2025-01 | |
| Tara Climate Foundation — Clean Energy Transition in Asiasource | Coefficient Giving | Tara Climate Foundation | | $10M | 2022-12 | |
| The Good Food Institute — General Support (2021)source | Coefficient Giving | The Good Food Institute | | $10M | 2021-10 | |
| RAND — AI Evaluation and Testingsource | Coefficient Giving | RAND | | $10M | 2025-09 | |
| The Humane League — General Support (2018)source | Coefficient Giving | The Humane League | | $10M | 2018-08 | |
| Alliance for Safety and Justice — General Support (December 2019)source | Coefficient Giving | Alliance for Safety and Justice | | $10M | 2019-12 | |
| Grant to "support Helix Nano running preclinical and Phase 1 trials of a pan-variant Covid-19 vaccine."source | FTX Future Fund | HelixNano | | $10M | 2022-01 | |
| GiveDirectly — General Support (January 2016)source | Coefficient Giving | GiveDirectly | | $10M | 2016-01 | |
| Helen Keller International — Vitamin A Supplementation (January 2020)source | Coefficient Giving | Helen Keller International | | $10M | 2020-01 | |
| Sightsavers — Deworming Programs (January 2019)source | Coefficient Giving | Sightsavers | | $10M | 2019-01 | |
| Redwood Research — General Support (2021)source | Coefficient Giving | Redwood Research | | $9M | 2021-11 | |
| Malaria Consortium — Nigerian ITN Campaignsource | Coefficient Giving | Malaria Consortium | | $9M | 2024-09 | |
| Institute for Progress — General Support (2023)source | Coefficient Giving | Institute for Progress | | $9M | 2023-03 | |
| Evidence Action — Iron and Folic Acid Supplementation in Indiasource | Coefficient Giving | Evidence Action | | $9M | 2022-09 | |
| Cincinnati Children’s Hospital Medical Center — Infant Immunome and Influenza Studies (Mary Staat)source | Coefficient Giving | Cincinnati Children’s Hospital Medical Center | | $9M | 2019-11 | |
| Nutrition International — Vitamin A Supplementationsource | Coefficient Giving | Nutrition International | | $9M | 2022-02 | |
| Centre for Effective Altruism — Harvard Square Coworking Spacesource | Coefficient Giving | Centre for Effective Altruism | | $9M | 2022-08 | |
| The Humane League — General Support (2024)source | Coefficient Giving | The Humane League | | $8M | 2024-10 | |
| Center for a New American Security — AI Security and Stability Programsource | Coefficient Giving | Center for a New American Security | | $8M | 2025-06 | |
| The Humane League — General Support (2022)source | Coefficient Giving | The Humane League | | $8M | 2022-10 | |
| The Humane League — General Support (2023)source | Coefficient Giving | The Humane League | | $8M | 2023-10 | |
| Stanford University — Infant Immunome Study (Mark Davis, Justin Sonnenburg, and Bali Pulendran)source | Coefficient Giving | Stanford University | | $8M | 2020-03 | |
| Fortify Health — Support for Expansionsource | Coefficient Giving | Fortify Health | | $8M | 2022-01 | |